Drug-dealing blood-brothers Keith and Kevin Banks are sitting on top of the world with enough dough and honeys to last them for sure. Just when everything seems to be going their way, jealousy secretly takes hold of their close friend, Tee. Knowing that women are Keith's weakness and downfall, Tee goes out of his way to bring Keith's success to a devastating halt by using the stunning, sexy Selina to set him up. But his plan falls short when Selina falls for Keith.

Keith's down chick and baby mama, Tukey, can't cope with the fact that Keith is with the home wrecker and begins to fall into the hands of a Lesbian named Anitra. Later realizing that she was only with Anitra because of her broken heart, Tukey attempts to regain Keith's love by taking a case for him, ending up behind bars. While she's down, she learns of Tee's plot. In an attempt to try and warn the love of her life, Tukey calls Keith only to find out that he has married Selina. Baffled, envious and full of rage, Tukey plans and carries out a plot so vicious, all the money in the world can't help Keith recover. Hoodwinked is followed by its sequel, In Cahootz.