Maurice Jones is a smooth, conniving player who specializes in manipulating young women for his own financial gain. Tired of dealing with the same naive women day after day, Maurice searches for the one female who can match his wit.

Nekole Mitchell is a scheming hood wench who slithers her way into Maurice's life, spreading her sweet but deadly venom amongst Maurice's circle of friends.

What begins as a game for Maurice turns into a Contagious cycle of lust, disgust, and murder, when everyone becomes a victim of their own stratagem.